To study this I focus on sequencing and analyzing genomes of organisms, especially microbes and using phylogenomic analysis View all posts by Jonathan Eisen. I lump this guy with other quacks, such as those who promote the false idea that vaccines cause autism. These are the snake oil salesmen of the internet age.

While most can be ignored, many play on the fears or desperation of those with chronic diseases that have no real cure. My mother is one example. Because she's pretty much exhausted all other therapies, it becomes very easy for her to find stuff like what this Marshall promotes, and wonder if it might help her. Like Like.

The antibiotics are used in low doses only. The hypotheses is to slowly restore innate immune system competence primarily with the aid of a VDR agonist thus allowing the host to sort out it's microbial content rather than doing it with direct brute intervention with high dose antibiotics. The science is still terribly lacking, and Trevor Marshall has discussed the problem of orders of complexity relating the human microbiome with chronic disease states.

I'm not sure if this one should get shit-canned so quickly. I note that despite your statement that Marshall has commented about the complexity, they still claim to have effectiveness against all of those diseases, yet they have yet to publish any evidence of that — still smelly like a scam to me.

My brother had Rhumatoid spelling? He has been on the Marshall protocal for several years and he is now back to work and has very few symptoms now! There is really no money being made by anyone. I appreciate the comment and accept that many people think the MP helps them. But anecdotal stories like this are not evidence … since many other things could have affected your brother's health status, including a placebo effects.

What I am looking for is any evidence that the MP works for the large array of health issues the supporters claim it does. I do not see really any such evidence. Given that there are many known and theoretical ris,s to the MP, I believe promoting it so strongly is a very very bad idea. As for a scam, I agree it does not seem to be a money making scam. But there are lots of other kinds of practices that are deceptive even if they do not go for money and even if they practitioners are trying to help.

They also make repeated overstatements of the known proven benefits of the MP. Call it whatever you want, but they need to clean up their act. I understand your point, but trust me when i say that mt brother was bed ridden! I has been nothing short of a miracle what has happened to him on the MP. I have Ulcerative Colitis and it has been getting worse.

I'm strongly considering doing the MP. My brothers doc wo wants to remain unknown due to the fact the MP isn't standard practice is absolutely blown away at my brothers recovery. I am serious! I's amazing. M whole family thought he was crazy at first, but now my siser who had Fibro is doing it and she has already begun to see the effects. I is true that these autoimmune diseases run in families as my brother has Arthritis, My older sister has MS, my Youngest sister has Fibro, and I have Ulcerative Colitis.

There is no Placibo effect on my brother. I also believe that the reason there hasn't been much follow up on this by research groups or whomever it would take to make this thing take off is because there isn't much money to be made because it doesn't involve any new drug.

The drugs used have been around and are very cheap. If there isn't money to be made, drug companies or whomever aren't interested. Thats just the world we live in….. Hello Jonathan, I think you have not understood the Marshall disease model. I imagine you, too, think that there has been a co-evolution of men and microbiota? Thus the next step to think that microbiota do exploit the human metobolism and vice versa is just a logical one.

Since new technology enables researchers to find microbiota via their DNA the Marshall thesis is supported every day by new studies. According to the Marshall disease model the therapy the Marshall Protocol supports the innate immune system via activating the VDR Vitamin D receptor which plays a pivotal role with olmesartan.

The amount of people having started the MP and show enormous improvements me included comply to a phase 2 clinical trial. Trevor Marshall and all interested in the MP wish for an official phase 3 trial.

But this costs money. As the MP uses already known drugs there is no big business in the MP for the pharma industry. YOu can be sure if there was a new drug the MP would have been an approven therapy for several years!! Money makes a world go round. So, if you want to prove the MP wrong, please give a donation to the Autoimmun Research Foundation which supports the MP to make a big trial more possible. When it is proven wrong you will have saved many, if it is proven right I am sure about that you will have helped a lot!

I and my wife are doing the MP. She for 4 months and I for 18 months. She suffers from many problems including frequent Migraine headaches and several other problems including food senitivities, aching body, mild chronic fatique and other things.

She has not had but one migraine since she started the MP 4 months ago after crying for 2 hours one night Much of the aching body goes and comes depending on the drug doses.

My skin rashes have gone away for the most parts, my sleeping has not been better in 20 years,and more. I personally know 5 other people that are on the MP and all are recovering from serious chronic illness.

Some are getting out of bed and even working for the first time in years. Most are, for the first time, in getting releif from their chronic illnesses. The biggest issue is to get doctors over the fear of the high doses of Olmesartan. One can read the info found on the on MP website, the web and Cipla website to see that it is perfectly safe in high doses. I spoke with a customer of mine last week that has studied Vitamin D for the last 8 years. To make a long story very short Dr.

Stender said that she had concerns about the MP but could see the possiblity of the protocol working. Sure there needs to be a lot of research done but until MP can come up with a hundred million dollars to prove their hypothesis in a way that scientist around the world will accept, we will just continue to be cured the best way we have found.

Every person on the MP has first gone to every doctor possible that could help them with no results in terms a cure for their illness. Only drugs are given to treat symtoms for the most part. These people desperate for help and they are getting it from the MP. No one is making money from the MP and that is the first definition of any scam!

This man, Trevor Marshall, is helping people help themselves since they cannot get it anywhere else. There is so much more I would like to say what you get my point!! My issue with the MP is the attempt by the supporters of it to overstate the evidence that it works. Certainly, many people think it works. And on the MP site and in many forums, the MP supporters make claims implying more evidence than exists. When people overstate evidence for a medical treatment such as this, I get very worried.

It suggests either purposeful deception or lack of understanding of science. Either one has potential to be dangerous. Again, I am not saying MP cannot work. I am saying that I have yet to see any evidence that it works.

Just because some people on MP improve does not mean it works — there are factors such as the placebo effect and sampling bias that need to be considered. For example, without data and clinical studies, it is hard to know how many people have started the MP and how many show no improvement. Testimonials from people who think it works are not enough.

And the MP people seem disinclined to state the current state of knowledge, which seems to me to be that we just don't know if this works for real. You need to go to the website and read the history over years of people posting how they are being healed from illnesses that are not curable.

These are not placebo affects. The percentages are never this high especially on uncurable diseases. Trevor openly admitted yesterday, on video, that we are just beginning to understand how this works and all the different pathways that are open to investigate. Please, most people trying this have given modern mainstream medicine every opportunity to help them and all they get are more drugs. Please don't discourage the hopeless sick people out there from trying this.

There are no other options except a life of pain and suffering. The MP has given data which show its success which would meet a phase 2 trial. Phase 3 trials are needed and for this money is needed. The Marshall Disease Model has a profound scientific basis. Jonathan, you repeat your former statements that without those phase 3 trials something is missing.

Randomised trials might be no problem but blinded is not possible regarding the kind of therapy. These are themes specialists for trial design have to think about. Nevertheless, a a responsible scientist should have informed himself thouroughly about the available data www. Nelson from the Craig-Venter-Institute. Trevor Marshall has written the chapter regarding autoimmune diseases.

I, naively, just imagine, that Karen E. Nelson did not fall for fairy tales? Testimonials are great and you can encourage people to participate. But I would like to see some sort of study where comprehensive data is presented and where careful controls are done. As for a book chapter — that does not really make any difference. The MP supporters need to conduct and publish a series of clinical studies testing how well the protocol works, comparing its effectiveness to other treatments and to placebo, and such.

I have yet to see any such studies published. All I am asking is that you please stop posting no offense meant in ignorance, things that would discourage someone from trying the MP. At some point after so many people are cured and none killed you have to say it works. The system here in the USA is set up for super rich companies to get approval. There simply will never be enough money to run FDA trials because no one can make money off of the MP.

Denise Faustman and the Mass. General Laboratory can't even get funding for her trials, from pharmaceutical corporations, with the BCG to [possibly] cure diabetes, because the drug is non-patentable.

It takes 1 billion dollars to bring a new drug to market and those companies need revenue. That revenue comes from patentable drugs. Christopher — I don't really follow.

How does Dr. Faustman's work connect to the Marshall Plan? For those of you who do NOT think that Dr. Marshall of the MP is a scam artist, consider this.

He is not a medical doc and while he now says he is a PhD in bio-engeneering, actually he holds Ph. This is of course in addition to the websites he has where he is selling stuff!

I would like to see his portfolio and see if that BP med he keeps pushing is part of it!! He also uses litigation threats to shut down any post or group including yahoo groups that dare speak out against him. Have you read some of his posts? If someone has the audacity to question him he is arrogant and rude and snarky to them… and this is on his own website! Erica First, how should Dr. Marshall sign his name that would make you happy?

Something like Dr. There are so many things I could say to you as a person that has been on the MP for 3 years but I will limit myself to just a few. First, you speak with so much foolishness and ignorance that it is hard to have an intelligent conversation. The issue here is not whether Trevor Marshall is a MD or how he speaks to the cohort when they ask him questions.

That is the first and really the only thing that matters. I personally know 8 people here in Memphis that have seen every medical doctor that they could possibly see to get help with their chronic illnesses with no results other than what steroids can do for a person.

With the Mp they are getting well and feel better than they have in at least 10 years. One lady one has been sick and in bed for 15 years. She is now getting ready to start a job!! My wife has not had a migraine for 15 months and used to suffer from them almost daily. Several have so many illnesses that I cannot list them all, mental and physical. A scam is where someone lies and deceives and makes money off the victims. Dr Marshall takes donations from the people that want to support what he is doing because they are getting better.

Stop reading about the MP from critics and go read what the science is and what the patients say that are on the MP! The treatment was published in a publication of Nature. Dr Marshall may not be a MD but that does not mean that he is a scam-artist, quack or deceiving thousands of sick people that report in their blogs that they are getting better after being on the MP for a few years.

Everyone of them has seen Medical Doctors for decades and only now are getting better. Pharmaceutical drugs have influenced at best and corrupted at worst, the practice of medicine. You should not go around pontificating about things which you obviously know nothing about. Jonathan — I found your blog post as a result of a recent curiosity I developed in researching scams. And let me tell you — just in case you're still on the fence about it — everything written on the marshall plan just reeks of pseudoscience.

This is just an FYI in case you've taken the criticisms in this thread to heart. Yes, the perils of googling and not discovering criticisms of the MP is largely why I wrote this post …. To call this a scam shows me that you are a scammer, not Trevor. You are the one that does not do his homework before you write trash on the IN. Maybe you work for some of the pharmaceutical companies that stand to loose big if this treatment ever became popular. Do you know who Craig Venter is?

He may be the most famous geneticist in the world. If not, he is probably most famous for mapping the human genome in the year If not you might want to research it. She edited a book that is call Metagenomics of the Human Body.

For more info follow the link. The Chapter is call, Autoimmune disease and the human metagenome. Look it up if you truly care about understanding what you write about.

Peer review is a very very very simple filter — a low bar. See Stop Deifying Peer Review for a discussion of this. One has to read the papers themselves and also see how other people respond to the papers to have any idea whether what is in a paper is sound.

As for having a chapter published in a book edited by someone from the JCVI — seriously? That is the bar you are setting? Book chapters are generally not even peer reviewed so that is an even lower bar.

How about presenting actual evidence that the MP has any effectiveness? How about — rather than review papers and commentaries the proponents of the MP could actually present some detailed data in some papers? Or maybe do a clinical trial? I think there is something to the MP because I'm severely vitamin d deficient and when i was prescribed some, it is making me worst.

I tried researching stories of people being on vitamin D and found a link. When I read the comments it seemed that they weren't getting better but getting worse. I think there is something about the VDR getting suppressed by vitamin d as Trevor Marshall has mentioned and avoiding vitamin d so that the VDR can work to help the immune system might be plausible. Vitamin D deficiency is related to many diseases… but what if this indicates that low Vitamin D points to disease?

People that are taking vitamin D seem to be getting worst not better. Vitamin d deficiency has been linked to thyroid problems, chronic fatigue, hair loss, bone problems etc. But how come supplementation is not helping people but hurting them? I want to add also that my mom is also vitamin D deficient and when she took the supplement as directed by her doctor, she broke out in disgusting zits that she never had before. It was so gross. I looked up online that other people where having the same problem.

Vitamin D making me sick, tired, sleepy, breakout, etc. If vitamin D deficiency is linked to a host of diseases why are we getting sicker with supplementation?

I'm thinking that for people that have disease there might be really something to our bodies lowering the vitamin d so that the Vitamin D receptors can work for our immune system.

They were saying that the VDR is responsible for over gene expression and to fight disease. I'm not on the MP, but I'm open to it. I'll let you know what happens. Oh yeah sorry I forgot to mention both my mom and I have problems with Hypothyroidism. She's on synthroid right now. I don't want to take any hormone yet as I heard that you'll be on it for life after you start.

I'm having problems with joint pain, gout, mood swings, depression, and weight gain. I was on anxiety meds and stopped because I just don't want to take it anymore. So yeah like I said I'll update after the protocol if I can somehow get on it. And even the googling around the web to find discussions of what people think Vit D does to them is still anecdotal.

We need to have more than just anecdotes but actual scientific studies. Note — I am not saying Vit D is a good thing — I don't know — it is not my area. Call me a conspiracy theorist or whatever, but thats just the world we live in.

I have witnessed the MP work on my Brother, and thats good enough for me. Call me a conspiracy theorist or whatever, but thats just the sad world we live in. The only proof i need is watching my brother go from being completely bed ridden with R arthritis to working and living a normal life.

This is why medicine is run by only the rich and the pharmaceutical companies. A cure for some disease that is cheap is considered junk or as you put it, a scam. BTW you need to look up the definition of a scam. The MP has no markings of a scam. No money is involved! I was involved with a start-up pharmaceutical company here in Memphis called Greystone that got a drug approved, It was done with much less evidence than the MP has an much less science.

I watched from the inside as they even talk 3M into licensing the drug. The drug work and it was approved without any real evidence that it worked. Everything was anecdotal evidence. If the public knew what I know about the process of getting a drug approved the would be suspect of the whole process of drugs being approved for medical use.

The MP is fantastic and your blog is the real scam going on here. I am very sympathetic to those suffering chronic illnesses like your brother. I know many who have been through such things and it is awful. And it is wonderful that he is doing better. But though you may believe the MP is what cured him, that is simply not enough evidence for me. There are many other possible explanations such as the placebo effect and that he got better for some other reason and that the MP was unconnected to it.

And thus there needs to be careful research into treatments that go beyond stories like yours. As for whether there is enough money available to do such studies I think there could be if there was more out there on case studies about the MP. There are simple presentations of cases describing patients, treatments, and outcomes so that others can at least have a summary of the details behind stories like the one you describe for your brother.

The medical literature is filled with s and s of case reports involving single patients. There are even journals deduced to publishing medical case reports.

It does not cost millions of dollars to write up one of these reports. It takes a bit of time of the MDs treating someone but usually not much more. There are case reports out there about every frigging topic one can imagine. So I ask — where are the case reports for all of these apparently successful uses of the MP? I am not saying having case reports would prove the effectiveness of the MP but at least that would give people something to examine in more detail.

And then, over time, if the MP really worked, one would see more and more case reports. While one can argue that pharma companies might not be interested in some treatments I think medical professionals want to help their patients generally. So where are all the case reports from these medical personnel making use of the MP? I could go on and on, but I won't Again, I am thrilled your brother has recovered.

But, call me a conspiracy theorist or a skeptic but I see no reason or evidence to believe the MP had anything to do with it or has actually helped anyone else.

BTY The paper in Cellular and Molecular immunology has several case studies that were done and noted in the paper. I agree.

I wonder if you have a chronic condition? I have and have been on antibiotic therapy for three years not Marshall Protocol. Some people may experience relief after implementing the Aden Protocol due to the placebo effect, however, sarcoidosis will not be cured simply by following this program, and it could worsen if not treated by a doctor. Be cautious of at-home remedies and treatments like this, for they could have harmful effects and also deter you from getting the treatment you really need.

The wide span of conditions that distributors are claiming MMS cures should be a red flag on its own. Autism, the flu, and sarcoidosis could not be more different, so how could they possibly all be cured by the same product? Furthermore, the FDA warns consumers to stay away from MMS because not only does it thwart a patient from starting helpful treatment, but the product itself can be dangerous and make patients even more sick. When mixed according to package directions, the product becomes bleach, which is incredibly dangerous and often fatal to consume.

This is yet another product on the market to give desperate, vulnerable people false hope in exchange for money. Sadly, there are a lot of people in the world who want to capitalize on the fear and desperation of sick, vulnerable people.

Just remember, if these cures really worked, they would be widely embraced by the medical community. Unfortunately, there is still a lot of work to be done before we can find the real cure for sarcoidosis. However, we would rather find a cure that is thoroughly researched, safe, and effective than one that could have adverse effects.

Learn more about how FSR is advancing research that will lead to new and improved treatments for sarcoidosis through our Disease Model Initiative. This can make finding reliable information on the disease and treatments difficult.

Marshall Protocol Trevor Marshall came up with a treatment for chronic inflammatory diseases like sarcoidosis that consists of five seemingly simple steps. The page is endorsed by the institution and is not the page of an individual presenting their personal opinion. Publisher: The Townsend Letter Group.

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